Publications 2

Pre-Dartmouth Publications

Kang, K.H., Lee, C., Delidakis, G., Jung, J., Richard-Le Goff, O., Lee, J., Kim, J.E., Charab, W., Bruhns, P., and Georgiou, G. An engineered human Fc variant with exquisite selectivity for FcγRIIIa_V158 reveals that ligation of FcγRIIIa mediates potent antibody dependent cellular phagocytosis with GM-CSF-differentiated macrophages . Front. Immunol. 10, 562 (2019)
Lee, J., Paparoditis, P., Horton, A.P., Frühwirth, A., McDaniel, J.R., Jung, J., Boutz, D.R., Hussein, D.A., Tanno, Y., Pappas, L., Ippolito, G.C., Corti, D., Lanzavecchia, A., and Georgiou, G. Persistent antibody clonotypes dominate the serum response to influenza over multiple years and repeated vaccinations . Cell Host Microbe. 25, 367-376 (2019)

Sharma, R., Al-Saleem, F., Panzer, J., Lee, J., Puligedda, R.D., Felicori, L.F., Kattala, C.D., Rattelle, A.J., Ippolito, G.C., Cox, R.H., Lynch, D.R., and Dessain, S.K. Monoclonal antibodies from a patient with anti-NMDA receptor encephalitis . Ann. Clin. Transl. Neurol. 5, 935-951 (2018)
Lee, J. and Georgiou, G. High-affinity IgA against microbial glycans . Nat. Immunol. 19, 514-515 (2018)
Chen, Y., Wohlbold, T.J., Zheng, N., Huang, M., Huang, Y., Neu, K.E., Lee, J., Wan, H., Rojas, T., Kirkpatrick, E., Henry, C., Palm, A.E., Stamper, C.T., Lan, L.Y., Topham, D.J., Treanor, J., Wrammert, J., Ahmed, R., Eichelberger, M.C., Georgiou, G., Krammer, F., and Wilson, P.C. Influenza infection in humans induces broadly cross-reactive and protective neuraminidase-reactive antibodies . Cell 173, 417-429 (2018)
Wang, B., DeKosky, B.J., Timm, M.R., Lee, J., Normandin, E., Misasi, J., Kong, R., McDaniel, R.M., Delidakis, G., Leigh, K.E., Niezold, T., Choi, C.W., Viox, E.G., Fahad, A., Cagigi, A., Ploquin, A., Leung, K., Yang, E.S., Kong, W., Voss, W.N., Schmidt, A.G., Moody, M.A., Ambrozak, D.R., Henry, A.R., Laboune, F., Ledgerwood, J.E., Graham, B.S., Connors, M., Douek, D.C., Sullivan, N.J., Ellington, A.D., Mascola, J.R., and Georgiou, G. Functional interrogation and mining of natively-paired human VH:VL antibody repertoires . Nat. Biotechnol. 36, 152-155 (2018)

Lee, C., Romain, G., Yan, W., Watanabe, M., Charab, W., Todorova, B., Lee, J., Triplett, K., Donkor, M., Lungu, O.I., Lux, A., Marshall, N.M., Lindorfer, M.A., Goff, O.R., Balbino, B., Kang, K.H., Tanno, H., Delidakis, G., Alford, C., Taylor, R.P., Nimmerjahn, F., Varadarajan, N., Bruhns, P., Zhang, Y.J., and Georgiou, G. IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions . Nat. Immunol. 18, 889–898 (2017)
Cotham, V.C., Horton, A.P., Lee, J., Georgiou, G., and Brodbelt, J.S. Middle-down 193-nm ultraviolet photodissociation for unambiguous antibody identification and its implications for immunoproteomic analysis . Anal. Chem. 89, 6498–6504 (2017)

Lee, J., Boutz, D.R., Chromikova, V., Joyce, M.G., Vollmers, C., Leung, K., Horton, A.P., DeKosky, B.J., Lee, C., Lavinder, J.J., Murrin, E.M., Chrysostomou, C., Hoi, K.H., Tsybovsky, Y., Thomas, P.V., Druz, A., Zhang, B., Zhang, Y., Wang, L., Kong, W., Park, D., Popova, L.I., Dekker, C.L., Davis, M.M., Carter, C.E., Ross, T.M., Ellington, A.D., Wilson, P.C., Marcotte, E.M., Mascola, J.R., Ippolito, G.C., Krammer, F., Quake, S.R., Kwong, P.D., and Georgiou, G. Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination . Nat. Med. 22, 1456–1464 (2016) * Cover article on the December 2016 issue of Nat. Med. * Highlighted in News and Views in Nat. Med.
Raymond, D., Stewart, S., Lee, J., Ferdman, J., Bajic, G., Do, K.T., Ernandes, M.J., Suphaphiphat, P., Settembre, E.C., Dormitzer, P.R., Guidice, G.D., Finco, O., Kang, T.H., Ippolito, G.C., Georgiou, G., Kepler, T.B., Haynes, B.F., Moody, M.A., Liao, H., Schmidt, A.G., and Harrison, S.C. Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain . Nat. Med. 22, 1465–1469 (2016)

Kelton, W., Mehta, N., Charab, W., Lee, J., Lee, C., Kojima, T., Kang, T., and Georgiou, G. IgGA: a “cross-isotype” engineered human Fc antibody domain that displays both IgG-like and IgA-like effector functions Chem. Biol. 21, 1603–1609 (2014)